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“Most sweeteners pass through the gastrointestinal tract without being digested”, the researchers write. Therefore the substances act directly on bacterial colonisation and on the composition of the gut. The gut microbiota’s composition in turn plays a central role in the regulation of many physiological processes, including the metabolism of sugar.
Antibiotics neutralise the effect
In order to test whether the gastrointestinal flora of the animals is actually involved in glucose intolerance, the researchers administered high dosage of the broad-spectrum antibiotics ciprofloxacin and metronidazole, which act on Gram-negative bacteria, to both the leaner and obese animal subjects. During the antibiotic treatment, the animals continue to drink sweetener-containing water. Already after four weeks of therapy the researchers were barely able to detect glucose-intolerance test differences between the fatter and leaner animals drinking sweetener and the control animals. What’s more, Vancomycin, targeted at Gram-positive bacteria, also led to this effect.
“These results suggest that the sweetener-induced glucose intolerance is caused by changes in the gut flora and the different proportions of its bacterial representatives”, the study authors conclude.
A further test was used to confirm this assumption: the scientists transferred the bacteria of the gastrointestinal flora of sweetener-drinking mice to microbe-free control mice. Already six days after the faecal transplant these mice were also suffering from glucose intolerance. Here was yet another indication for the researchers that sweeteners, via the modulation of the intestinal flora, lead to a precursor form of type 2 diabetes.
http://news.doccheck.com/en/newsletter/1473/9911/
2024.04.23 - 17:10:52
