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Vitamins A, D and K cooperate to protect our soft tissues from calcification, to nourish our bones and teeth, and to provide children with adequate growth. We obtain these nutrients together by consuming organ meats, cod liver oil, fatty fish, grass-fed animal fats, green and orange vegetables, and fermented plant foods.

When large imbalances between vitamins A and D favor vitamin A, phosphorus accumulates at the expense of calcium, promoting bone loss.16 Vitamin A may also overwhelm the storage capacity of the liver under these conditions, contributing to liver damage. When the imbalance favors vitamin D, calcium accumulates in soft tissues, leading to stones in the kidney and bladder, and calcification of the blood vessels and aortal valves.13

Bra. Och sen rapporterar du va? Jag har väldigt svårt att fatta nu för tiden. :smile:

When the imbalance favors vitamin D, calcium accumulates in soft tissues, leading to stones in the kidney and bladder, and calcification of the blood vessels and aortal valves.

Njurstenar delas efter kemisk sammansättning in i fyra olika huvudtyper. De är kalciumsten, infektionssten, uratsten och cystinsten. Vanligast är kalciumstenar som består av kalciumoxalat och/eller kalciumfosfat. Ca 90% av alla njurstenar är kalciumstenar. Näst vanligast är infektionssten som består av karbonatapatit och/eller magnesiumammoniumfosfat. Ca 5% av alla njurstenar är infektionsstenar. Tredje vanligaste typ är uratstenar. Ca 3% av alla njurstenar är uratstenar. Mest ovanlig är cystinsten. Bara 1% av alla njurstenar är cystinstenar. Njurstenar kan även vara kombinationer av flera stentyper.
 
Normalt innehåller urin kemikalier så som magnesium, pyrofosfat och citrat som motverkar att saltkristaller bildas. Lider kroppen brist på dessa ökar risken för njursten. Forskning har visat att citrat är den mest betydelsefulla kemikalien för att förebygga njursten.

Normalt innehåller urin kemikalier så som magnesium, pyrofosfat och citrat som motverkar att saltkristaller bildas.

Vitamin D *supplements* may be making your "metabolic rate" much slower/worse. Why? One big reason is that they cause you to waste potassium through the kidneys. I don't have time for a whole blog post on this [well, after typing this up, maybe I did, I realized], and Matt and I did a whole 180D Radio podcast on the Vitamin D and calcium excess issue, so I will keep this as short as I can and mostly potassium-related.
First, Vitamin D *supplements* (not the sun-derived stuff) cause the body to retain calcium in the tissues and then waste potassium through the kidneys. This is referred to as hypercalcemia and hypokalemia, respectively.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC291035/?page=1
In rats:
"The moderate renal wastage of potassium caused by vitamin D is most clearly appreciated when the kidneys are being maximally stimulated to retain this ion (i.e., after prior deprivation of potassium). It might be anticipated that renal losses of potassium secondary to hypercalcemia would produce potassium deficiency in patients only when food intake had been substantially reduced; in a preliminary survey this appeared to be the case (3). Nevertheless, it is noteworthy that in experiments in which potassium intake was not restricted, the potassium content of muscle was significantly lower in rats treated with vitamin D than in control animals (25)."

If you look in the research, hypercalcemia is well established from excess Vitamin D intake in humans as well, so hypokalemia can also be assumed from the above mechanism shown in rats. The optimal dose of potassium daily is nearly 5000mg. The number of people getting that intake from food alone is about as rare as a happy person at a low-carb convention. This combo (low intake + wasting) doesn't fare well long-term.
I can tell you that in my patients & clients who take Vitamin D supplements long enough, I often see that their blood tests eventually show high calcium and low potassium. This is reflected much earlier on their hair mineral analysis (so much so that I refer to it as a vitamin D pattern, high calcium and nearly non-existent potassium).
Anyway, now to the money part of today's post. Low potassium. I'm assuming that I'm talking to people who are eating a "normal" mixed diet (not raw vegan or fruitarian nonsense) and salt their food, like the seasoned 180D person. Symptoms of low blood and/or low hair potassium--and realize that one can have symptoms of subclinical, aka "you have the problems but it doesn't show on your yearly blood test"--from Medline Plus:
http://www.nlm.nih.gov/medlineplus/ency/article/000479.htm

"Symptoms
A small drop in potassium level often does not cause symptoms. Or symptoms may be mild and include:
Abnormal heart rhythms (dysrhythmias), especially in people with heart disease
Constipation <--
Feeling of skipped heart beats or palpitations
Fatigue <--
Muscle damage
Muscle weakness or spasms
Tingling or numbness
A large drop in potassium level may slow your heartbeat. This can cause you to feel lightheaded or faint. A very low potassium level can even cause your heart to stop."

MORAL: Get your Vitamin D from the sun or other full-spectrum lights. Your body has major control over your D levels this way. Stop screwing up your tissue (cellular) calcium and potassium levels with Vitamin D supplements...which will likely be the biggest bust and cause the most long-term problems of any supplement fad EVER.
One last thing: Fixing the magnesium deficiency that I see in ***everyone*** will likely fix that Vitamin D deficiency of yours:
http://www.ncbi.nlm.nih.gov/pubmed/23981518

"CONCLUSIONS: Our preliminary findings indicate it is possible that magnesium intake alone or its interaction with vitamin D intake may contribute to vitamin D status. The associations between serum 25(OH)D and risk of mortality may be modified by the intake level of magnesium."
--Dr. G

Ja dt är väldigt generella symptom som stämmer in på rätt många sjukdomstillstånd.
Men det kan ju också vara så att det är ett grundproblem som är starten och som utvecklas vidare till olika sjukdomar hos olika människor.

Epiphany time! As I read about this precious nutrient, it suddenly made sense: vitamin K2 is a product of bacterial fermentation, and the “probiogurt” I’d been eating was likely teeming with it. It was probably the first food-based source of K2 my body had seen in years. After that “aha” moment, I started religiously supplementing with vitamin K2 — 5 milligrams a day from Carlson Labs. (That’s still the brand and dosage I use to this day.)

Shazzam. Practically overnight, my teeth felt smoother, looked whiter, and lost a great deal of their painful sensitivity. And at my next dental cleaning, the hygienist confirmed a turn for the better: some of my “irreversibly” lost enamel was thickening; a few pre-cavity trouble spots were filling in on their own; and the periodontal pockets that’d been getting gradually worse were suddenly tightening back up — jumping from measurements of 4-5 millimeters on most teeth to 2-3. My lost-cause mouth was suddenly not so lost. Allow me to repeat: shazzam!

Är det så att 10 x 100microgram är 1 milligram?

Svarar han på mail? Imponerande! Fast det är klart, jag är ju redan omponerad av att han svarar på frågor i kommentarerna och deltar i diskussionerna. Inte alla som visar sådant intresse, minsann. :whistle:

Aspirin is an antioxidant that protects against lipid peroxidation, but it also stimulates mitochondrial respiration. It can inhibit abnormal cell division, but promote normal cell division. It can facilitate learning, while preventing excitotoxic nerve injury. It reduces clotting, but it can decrease excessive menstrual bleeding. These, and many other strangely beneficial effects of aspirin, strongly suggest that it is acting on very basic biological processes, in a coherent way.

"When the diet lacks calcium, there is an increase in fatty acid synthase, an enzyme that converts calories into fat. Higher levels of calcium with adequate vitamin D inhibit this enzyme, while diets low in calcium increase this enzyme by as much as fivefold. More of this enzymes activity means more fat getting stored from calories coming in. In one study, genetically obese rats lost 60 percent of their body fat in six weeks on a diet that had moderate calorie reduction but was high in calcium. All rats supplemented with calcium showed increased body temperature, indicating a shift from calorie storage to calorie burning (a process known as thermogenesis). What this means is that in the presence of calcium and Vitamin D, the body turns down the volume on this fat-storing enzyme. Without adequate calcium and vitamin D available, the body turns up the volume on this fat-storing enzyme, and what you ned up with is just that - a higher volume of fat working against everything an individual would like to see happen in his or her body." - Dr. Michael Holick "The Vitamin D Solution"

Dr. Holick recommends 3 glasses of milk a day plus an additional 1200mg calcium in divided doses with meals to aid absorption. He recommends sunshine 10 minutes 3x a week minimum plus an additional 3000-4000 IU Vitamin D for most people regardless of blood levels. He used to be a dermatologist but was kicked out of the association for being too "Pro Sun Exposure". He is doing research on other photonutrients we get from the sun, apparently there are about 5-10 types of nutrients we can get from the sun besides Vitamin D. That research is still in it's infancy but kind of interesting...